Amiodarone-induced thyroid dysfunction associated with cumulative dose
نویسندگان
چکیده
منابع مشابه
Amiodarone-induced thyroid dysfunction.
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متن کاملAmiodarone-induced thyroid dysfunction.
BACKGROUND Little is known about the frequency of thyroid dysfunction (TD) associated with amiodarone therapy in southern Africa. OBJECTIVES To determine the incidence of TD in a cohort of patients initiated on amiodarone therapy at a cardiac clinic in Cape Town, South Africa, believed to be an iodine-replete area. PATIENTS Pharmacy records were used to obtain the names of patients who rece...
متن کاملAmiodarone-induced thyroid dysfunction in clinical practice.
Amiodarone is a potent class III anti-arrhythmic drug used in clinical practice for the prophylaxis and treatment of many cardiac rhythm disturbances, ranging from paroxismal atrial fibrillation to life threatening ventricular tachyarrhythmias. Amiodarone often causes changes in thyroid function tests mainly related to the inhibition of 5'-deiodinase activity resulting in a decrease in the gene...
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Introduction: Previous cohort studies reported contradictory data on the association between subclinical thyroid dysfunction and coronary heart disease (CHD). Regarding this, the present study was conducted to illuminate this relationship. Materials and Methods: For the purpose of the study, 3,066 participants employed in a study conducted by Azizi et al. aged ≥ 20 years were subjected to thyro...
متن کاملAmiodarone and the thyroid dysfunction
Amiodarone, a class III antiarrhytmic agent, is a benzofuran derivative containing 75 mg iodide per 200 mg tablet. During the metabolism of 200 mg of the drug approximately 6-8 mg of inorganic iodine is released into the systemic circulation. Amiodarone is very lipophilic and concentrates in various tissues and organs such as adipose tissue, skeletal muscles, myocardium, liver, lung and thyroid...
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ژورنال
عنوان ژورنال: Pharmacoepidemiology and Drug Safety
سال: 2002
ISSN: 1053-8569,1099-1557
DOI: 10.1002/pds.735